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KMID : 0363320050260020369
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Journal of Korean Oriental Internal Medicine
2005 Volume.26 No. 2 p.369 ~ p.378
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Single Dose Toxicity Test of Bojungikkeehapdaechilkitang water extract in Male and Female ICR Mice
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Bae Young-Chul
Choi Bin-Hye
Kim Dong-Woo
Hur Jin-Il
Byun Joon-Seok
Kim Dae-Jun
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Abstract
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An herbal water extract of Bojungikkeehapdaechilkitang(BDT) was prepared to test it for single-dose and repeated-dose toxicity, genotoxicity and reproductive toxicity, and to obtain a 50% lethal dose(LD_{50}), approximated lethal dose(ALD), and approximated target organs for BDT. The extract was tested on female and male ICR mice according to KFDA Guideline 1999-61 at doasge level of 2000, 1000, 500, 250 and 125mg/kg/10mL In this study, clinical signs, mortalities and gross findings of principal organs were observed for 14 days of single dosing, and afterwards in some cases. The ALD and $LD_{50}$ of BDT extract obtained in this study was>2000mg/kg for both male and female ICR mice. Also, any possible digestive toxicity of BDT extract was found to be above 1000mg/kg in both male and female ICR mice. The results of this study strongly suggest that BDT extract has no toxic effect at dosage level below 500mg/kg.
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KEYWORD
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LD_{50}, ALD, Bojungikkeehapdaechilkitang, dose toxicity
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